ОЦЕНКА ВЗАИМОСВЯЗИ ПОЛИМОРФИЗМОВ ГЕНОВ СОМАТОТРОПНОГО КАСКАДА С РОСТОВЫМИ ХАРАКТЕРИСТИКАМИ КРУПНОГО РОГАТОГО СКОТА

А.М. Наметов; И.С. Бейшова; Е.В. Белая; Т.В. Ульянова; С.А. Черняева

doi:10.37884/3-2022/03

Abstract

The article presents the results of a study of the growth dynamics of the Aberdeen Angus breed by the genes of the somatotropic cascade (growth hormone (bGH), growth hormone receptor (bGHR) and insulin-like growth factor-1 (bIGF-1).

The work was carried out in the Department of Molecular Genetic Research of the Research Institute of Applied Biotechnology of A. Baitursynov Kostanay Regional University and in the laboratory of Biotechnology and Diagnostics of Infectious Diseases of Zhangir Khan West Kazakhstan Agrarian Technical University. The object of the study was the animals of the Aberdeen-Angus breed (n=200), bred in the «Север Агро-Н» LLP of the Kostanay region. Animal genotypes by polymorphisms bGH-AluI, bGHR-SspI, and bIGF-1-SnaBI were established by PCR-RFLP. Based on the results of genotyping, groups of animals were formed taking into account the genotypes of the bGH, bGHR, bIGF-1 genes, and groups of animals were formed taking into account paired combinations of their genotypes (diplotypes). Signs were studied in cattle: live weight at the ages of 9, 12, 18 and 24 months, absolute and average daily gains.

It was found that in the group of animals of the Aberdeen Angus breed, the diplotypes bGH-AluI^LL-bIGF-1-SnaBI^AA, bGH-AluI^LL-bIGF-1-SnaBI^BB, and bGH-AluI^VV-bIGF-1-SnaBI^BB are the most preferred since they are associated with increased growth rates. The results obtained indicate the undesirability of the bGH-AluI^LV genotype, as well as combinations of the bGH-AluI^LV-bGHR-SspI^FY, and bGHR-SspI^FF-bIGF-1-SnaBI^BB genotypes. Thus, genotypes and diplotypes that have an increasing effect on meat productivity indicators had a positive effect on live weight, absolute and average daily gains, and vice versa, genotypes and diplotypes associated with low productive qualities of cattle were associated with the lowest growth rates; which confirms the expediency of their use as genetic markers.

Aberdeen Angus breed live weight absolute gain average daily gain polymorphism growth hormone gene (bGH) growth hormone receptor gene (bGHR) insulin-like growth factor-1 gene (bIGF-1)

01 Introduction

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02 References

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3. Зеленков П.И., Бараников А.И., Зеленков А.П. Скотоводство. - Ростов-на-Дону: «Феникс», 2006. - 572 с.
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5. Shaikamal G., Ulyanov V., Ulyanova T. et al. Productive longevity of cows depending on the genotype of the growth hormone gene // Ecology, Environment and Conservation. – 2020. – V. 26(4). – P. 1606-1609.
6. Nametov A.M., Beishova I.S., Chuzhebaeva G.D. et al. Assessment of pairwise combinations’ association of polymorphic variants of the genes of Bpit-1, Bgh, Bghr Bigf somatotropic cascade with meat productivity of the cattle bred in Kazakhstan // Journal of Pharmaceutical Sciences and Research. – 2018. – V. 10(8). – P. 1906-1911.
7. Dushayeva L.Zh., Beishova I.S. Ulyanova T.V. et al. Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle // OnLine Journal of Biological Sciences. – 2021. – V. 21(2). – P. 334-345.
8. Skinkytė R., Zwierzchowski L., Riaubaitė L. et al. Distribution of allele frequencies important to milk production traits in lithuanian black & white and lithuanian red cattle // Veterinarija ir zootechnika. – 2005. – V. 31(53). – Р. 93-97.
9. Fontanesi L., Scotti E., Tazzoli M. et al. Investigation of allele frequencies of the growth hormone receptor (GHR) F279Y mutation in dairy and dual-purpose cattle breeds // Italian Journal of Animal Science. – 2007. – V. 6. – P. 415-420.
10. Siadkowska E., Zwierzchowski L., Oprządek J. et al. Effect of polymorphism in IGF-1 gene on production traits in Polish Holstein-Friesian cattle // Animal Science Papers and Reports. – 2006. – V. 24. – P. 225-237.
11. Овсянников А.И. Основы опытного дела в животноводстве. – М.: Колос, 1976. – 304с.
12. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. – М.: «МедиаСфера», 2002. – 312 с.
13. Рокицкий П.Ф. Основы вариационной статистики для биологов. - Минск: БГУ, 1961 – 224 с.
14. Hartatik T., Fathoni A., Bintara S., Ismaya, Panjono, Widyobroto B.P., Ali Agus, Igs. Budisatria, Leroy P. The genotype of growth hormone gene that affects the birth weight and average daily gain in crossbred beef cattle // Biodiversitas. – 2020. – V. 21 (3). – P. 941-945.
15. Плахтюкова В.Р. Полиморфизм генов кальпаина и соматотропина у крупного рогатого скота казахской белоголовой породы и его связь с показателями продуктивности // дисс. соискание ученой степени кандидата биологических наук. - 06.02.07 – разведение, селекция и генетика сельскохозяйственных животных. – 2020, Ставрополь. – 142 с.
16. Fedota O.M., Ruban S. Yu., Lysenko N. G., Kolisnyk A. I., Goraichuk I. V., Tyzhnenko T. V. SNP L127V of growth hormone gene in breeding herd of aberdeen angus in Kharkiv region, Eastern Ukraine // Journal for Veterinary Medicine, Biotechnology and Biosafety. – 2016. - V. 2(3). – P. 5-11.
17. Sedykh Т.А., Dolmatova I.Y., Valitov F.R., Gizatullin R.S., Kalashnikova L.A. The Influence of Growth Hormone Gene Polymorphism on Growth Rate of Young Cattle // Iranian Journal of Applied Animal Science. – 2020. - V.10(3). – P. 445-451.
18. Akcay A., Akyüz B., Bayram, D Determination of the AluI polymorphism effect of bovine growth hormone gene on carcass traits in Zavot cattle with analysis of covariance // Turkish journal of veterinary and animal sciences. – 2015. – V.39. - P. 16-22.
19. Plivachuk О., Dyman T. Interdependence of complex genotypes of alfa-lactalbumin and beta-lactoglobulin with composition and technological properties of milk of ukrainian black-and-white dairy cattle // Animal Breeding and Genetics. – 2018. – V.51. – P. 124-131.
20. Maurić M., Mašek T., Beniæ M., Špehar M., Starèeviæ K. Effect of DGAT1, FASN and PRL genes on milk production and milk composition traits in Simmental and crossbred Holstein cattle // Indian Journal of Animal Sciences. – 2017. – V.87. – P. 859-863.

Citation Links

[1]2022. EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. Izdenister natigeler. 3 (95) (Sep. 2022), 21–31. DOI:https://doi.org/10.37884/3-2022/03.

(1)EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. Izdenister natigeler 2022, No. 3 (95), 21-31. https://doi.org/10.37884/3-2022/03.

EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. (2022). Izdenister Natigeler, 3 (95), 21-31. https://doi.org/10.37884/3-2022/03

EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. Izdenister natigeler, [S. l.], n. 3 (95), p. 21–31, 2022. DOI: 10.37884/3-2022/03. Disponível em: https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/140. Acesso em: 15 sep. 2026.

“EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE”. 2022. Izdenister Natigeler, no. 3 (95) (September): 21-31. https://doi.org/10.37884/3-2022/03.

“EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE” (2022) Izdenister natigeler, (3 (95), pp. 21–31. doi:10.37884/3-2022/03.

[1]“EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE”, Izdenister natigeler, no. 3 (95), pp. 21–31, Sep. 2022, doi: 10.37884/3-2022/03.

“EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE”. Izdenister Natigeler, no. 3 (95), Sept. 2022, pp. 21-31, https://doi.org/10.37884/3-2022/03.

“EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE”. Izdenister natigeler, no. 3 (95) (September 30, 2022): 21–31. Accessed September 15, 2026. https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/140.

1.EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. Izdenister natigeler [Internet]. 2022 Sep. 30 [cited 2026 Sep. 15];(3 (95):21-3. Available from: https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/140

1.EVALUATION OF THE RELATIONSHIP OF POLYMORPHISMS OF SOMATOTROPIC CASCADE GENES WITH THE GROWTH CHARACTERISTICS OF CATTLE. Izdenister natigeler. 2022;(3 (95):21-31. doi:10.37884/3-2022/03

[1] 1. Шевхужев А., Мамбетов М., Бостанов А. Откорм бычков разных генотипов при промышленной технологии // Молочное и мясное скотоводство. - 2008. - № 6. - С. 8–10.

[2] 2. Завьялов О.А., Харламов А.В., Харламов В.А. Экономическая эффективность выращивания на племя бычков казахской белоголовой породы разных сезонов рождения // Вестник мясного скотоводства. - 2009. – № 62. – С. 88-91.

[3] 3. Зеленков П.И., Бараников А.И., Зеленков А.П. Скотоводство. - Ростов-на-Дону: «Феникс», 2006. - 572 с.

[4] 4. Ulyanov V.A., Kubekova B.Z., Beishova I.S. et al. Preferred and undesirable genotypes of bGH and bIGF-1 genes for the milk yield and quality of black-and-white breed // Veterinary World. – 2021. – V. 14(5). – P. 1202-1209.

[5] 5. Shaikamal G., Ulyanov V., Ulyanova T. et al. Productive longevity of cows depending on the genotype of the growth hormone gene // Ecology, Environment and Conservation. – 2020. – V. 26(4). – P. 1606-1609.

[6] 6. Nametov A.M., Beishova I.S., Chuzhebaeva G.D. et al. Assessment of pairwise combinations’ association of polymorphic variants of the genes of Bpit-1, Bgh, Bghr Bigf somatotropic cascade with meat productivity of the cattle bred in Kazakhstan // Journal of Pharmaceutical Sciences and Research. – 2018. – V. 10(8). – P. 1906-1911.

[7] 7. Dushayeva L.Zh., Beishova I.S. Ulyanova T.V. et al. Marking of Meat Productivity Features in Pairs of bGH, bGHR and bIGF-1 Polymorphic Genes in Aberdeen-Angus Cattle // OnLine Journal of Biological Sciences. – 2021. – V. 21(2). – P. 334-345.

[8] 8. Skinkytė R., Zwierzchowski L., Riaubaitė L. et al. Distribution of allele frequencies important to milk production traits in lithuanian black & white and lithuanian red cattle // Veterinarija ir zootechnika. – 2005. – V. 31(53). – Р. 93-97.

[9] 9. Fontanesi L., Scotti E., Tazzoli M. et al. Investigation of allele frequencies of the growth hormone receptor (GHR) F279Y mutation in dairy and dual-purpose cattle breeds // Italian Journal of Animal Science. – 2007. – V. 6. – P. 415-420.

[10] 10. Siadkowska E., Zwierzchowski L., Oprządek J. et al. Effect of polymorphism in IGF-1 gene on production traits in Polish Holstein-Friesian cattle // Animal Science Papers and Reports. – 2006. – V. 24. – P. 225-237.

[11] 11. Овсянников А.И. Основы опытного дела в животноводстве. – М.: Колос, 1976. – 304с.

[12] 12. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. – М.: «МедиаСфера», 2002. – 312 с.

[13] 13. Рокицкий П.Ф. Основы вариационной статистики для биологов. - Минск: БГУ, 1961 – 224 с.

[14] 14. Hartatik T., Fathoni A., Bintara S., Ismaya, Panjono, Widyobroto B.P., Ali Agus, Igs. Budisatria, Leroy P. The genotype of growth hormone gene that affects the birth weight and average daily gain in crossbred beef cattle // Biodiversitas. – 2020. – V. 21 (3). – P. 941-945.

[15] 15. Плахтюкова В.Р. Полиморфизм генов кальпаина и соматотропина у крупного рогатого скота казахской белоголовой породы и его связь с показателями продуктивности // дисс. соискание ученой степени кандидата биологических наук. - 06.02.07 – разведение, селекция и генетика сельскохозяйственных животных. – 2020, Ставрополь. – 142 с.

[16] 16. Fedota O.M., Ruban S. Yu., Lysenko N. G., Kolisnyk A. I., Goraichuk I. V., Tyzhnenko T. V. SNP L127V of growth hormone gene in breeding herd of aberdeen angus in Kharkiv region, Eastern Ukraine // Journal for Veterinary Medicine, Biotechnology and Biosafety. – 2016. - V. 2(3). – P. 5-11.

[17] 17. Sedykh Т.А., Dolmatova I.Y., Valitov F.R., Gizatullin R.S., Kalashnikova L.A. The Influence of Growth Hormone Gene Polymorphism on Growth Rate of Young Cattle // Iranian Journal of Applied Animal Science. – 2020. - V.10(3). – P. 445-451.

[18] 18. Akcay A., Akyüz B., Bayram, D Determination of the AluI polymorphism effect of bovine growth hormone gene on carcass traits in Zavot cattle with analysis of covariance // Turkish journal of veterinary and animal sciences. – 2015. – V.39. - P. 16-22.

[19] 19. Plivachuk О., Dyman T. Interdependence of complex genotypes of alfa-lactalbumin and beta-lactoglobulin with composition and technological properties of milk of ukrainian black-and-white dairy cattle // Animal Breeding and Genetics. – 2018. – V.51. – P. 124-131.

[20] 20. Maurić M., Mašek T., Beniæ M., Špehar M., Starèeviæ K. Effect of DGAT1, FASN and PRL genes on milk production and milk composition traits in Simmental and crossbred Holstein cattle // Indian Journal of Animal Sciences. – 2017. – V.87. – P. 859-863.