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STOCK-RAISING AND VETERINARY

STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS

A.A. Abdualiуeva 1 , J.M. Batanova 1 , N.N. Akhmetsadykov 2 , D.M. Khusainov 1 , A. Valdovskaya 3

1 NJSC “Kazakh National Agrarian Research University”, Almaty, Kazakhstan; 2 Scientific and Production Enterprise "Antigen" LLP, Almaty region, Kazakhstan; 3 Latvian Agricultural University, Jelgava

doi.org/10.37884/4-2022/05 pp. 36-43 Admitted 28.12.2022 Published 30.12.2022

Abstract

The scientific research work focuses on determining the immunogenic activity of the vaccine «Rhabdovac®» against animal rabies in industrial settings.

The primary objective of this study is to determine the immunogenic properties of the anti-rabies vaccine «Rhabdovac®» by conducting industrial tests on animals, in order to evaluate the immunogenic activity of the vaccine based on its ability to induce the production of antibodies via the anti-rabies viral neutralization reaction.

During the research, the inactivated liquid vaccine «Rhabdovac®», against animal rabies, was vaccinated once to 5 sheep aged 4-12 months (test protocol No. 33, 07/14/2019) at the livestock farm of the research and production enterprise «Antigen». Vaccine «Biocan-R» was used as a reference for comparative determination of the result and was vaccinated to 5 sheep aged 4-12 months. 5 healthy, unvaccinated sheep were used as controls. Sheep were checked for rabies antibodies prior to the study. Also in our subsequent study, we examined the dynamics of titer in the virus immunogenic activity neutralization response over a period of 12 months following subcutaneous administration of the «Rhabdovac®» vaccine with immunogenic activity of 2.0 IU/ml to four 2-5 months-old dogs in the vivarium of the scientific and production enterprise «Antigen» (test protocol No. 29, 07.02.2020).

As a result of the research, the immunogenicity of the rabies vaccine «Rhabdovac®» on animals in industrial conditions was determined by the virus neutralization reaction.

cell growth, Virus, Rabies, vaccination, antigen, neutralization reaction, immunogenic

01 Introduction

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02 References

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Citation Links

[1]2022. STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. Izdenister natigeler. 4 (96) (Dec. 2022), 36–43. DOI:https://doi.org/10.37884/4-2022/05.
(1)STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. Izdenister natigeler 2022, No. 4 (96), 36-43. https://doi.org/10.37884/4-2022/05.
STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. (2022). Izdenister Natigeler, 4 (96), 36-43. https://doi.org/10.37884/4-2022/05
STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. Izdenister natigeler, [S. l.], n. 4 (96), p. 36–43, 2022. DOI: 10.37884/4-2022/05. Disponível em: https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/176. Acesso em: 15 sep. 2026.
“STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS”. 2022. Izdenister Natigeler, no. 4 (96) (December): 36-43. https://doi.org/10.37884/4-2022/05.
“STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS” (2022) Izdenister natigeler, (4 (96), pp. 36–43. doi:10.37884/4-2022/05.
[1]“STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS”, Izdenister natigeler, no. 4 (96), pp. 36–43, Dec. 2022, doi: 10.37884/4-2022/05.
“STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS”. Izdenister Natigeler, no. 4 (96), Dec. 2022, pp. 36-43, https://doi.org/10.37884/4-2022/05.
“STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS”. Izdenister natigeler, no. 4 (96) (December 30, 2022): 36–43. Accessed September 15, 2026. https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/176.
1.STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. Izdenister natigeler [Internet]. 2022 Dec. 30 [cited 2026 Sep. 15];(4 (96):36-43. Available from: https://agrosoil.kaznaru.edu.kz/index.php/research/article/view/176
1.STUDY OF THE IMMUNOGENIC ACTIVITY OF THE VACCINE «RHABDOVAS®» AGAINST ANIMAL RABIES IN INDUSTRIAL CONDITIONS. Izdenister natigeler. 2022;(4 (96):36-43. doi:10.37884/4-2022/05